Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function.The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs).We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4, is selecti
In China, the government and the Power Resistance With Wire cigarette industry yearly lose millions in sales and tax revenue because of imitation cigarettes.Usually, visual observation is not enough to identify counterfeiting.An auxiliary analytical method is needed for cigarette brands identification.To this end, we developed a portable, low-cost
The seismic damage of underground structures has been extensively investigated, and it has been demonstrated that underground structures located at weak interlayer sites are more prone to damage.In this study, a two-story two-span rectangular frame subway station structure is analyzed.A two-dimensional soil-underground structure model is developed